$225,000

Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital

In September 2023, we awarded $225,000 to the Vaccine and Immunotherapy Center to fund the work of Mark C Poznansky, MD, PhD, and Ruxandra F. Sirbulescu, Ph.D. Specifically, we supported the Phase 1 Study of Repeated Infusion of Donor B Cells into Patients Diagnosed with ALS.

The B-cell is a key regulatory cell in the immune system; it acts by producing antibodies, antigen-presenting cells, supporting other mononuclear cells, and contributing to inflammatory pathways directly. This study involves repeated infusion of donor B-cells into patients diagnosed with ALS. Two patients with advanced ALS have to date received such infusions, which, even when repeated, appear to be safe and well-tolerated. The purpose of this study is to establish a more substantial basis for the safety of this procedure in humans and to begin to understand the effects of B-cell dosing on a patient's disease progression and immunologic profile.

More information about the Vaccine & Immunotherapy Center

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