$250,000

Sean M. Healey & AMG Center for ALS

In February 2024, we funded Dr. Matthew Nolan’s Exploring the Effect of Statins to Restore Stathmin-2 Function and Promote Motor Neuron Regeneration. Dr. Matthew Nolan’s research will be conducted under the direction of Clotilde Lagier-Tourenne, MD, PhD, with administrative oversight by Merit Cudkowicz, MD, MSc. Dr. Nolan conducted large-scale drug screens to identify compounds that might target and re-normalize STMN2 levels which contribute to abnormal TDP-43 levels in ALS patients. Surprisingly, one of the drug classes that appeared to show benefit was a class of medications called statins – compounds widely used to lower cholesterol in individuals with heart disease. This remarkable finding suggests there could be a role for statin treatment in people with ALS.

‍More information about Dr. Matthew Nolan